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Yeh-Chung Chang, MD $$

Infectious Disease Specialist

Assistant Professor at UT Southwestern Medical Center

Languages Spoken:
English

Locations

UT Southwestern Pediatric Group

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Biography

Yeh-Chung Chang, M.D., is an Infectious Disease Specialist at Children’s Health℠ and Assistant Professor of Pediatrics at UT Southwestern Medical Center. He has a special interest in the prevention, evaluation and treatment of viral and fungal infections in patients who are immunocompromised or have weakened immune systems. This includes patients who have received a solid organ transplant, a stem cell transplant, or are undergoing chemotherapy. 

“The immune system does an amazing job of fighting infections,” Dr. Chang said. “But sometimes, we need to change the immune system to help a transplant work or to treat cancer. When we do that, we create vulnerabilities that germs can take advantage of. The good news is that we have many weapons to help prevent and treat infections.”

I very much enjoy the team aspect of transplant medicine and immunocompromised infectious disease care and working with other specialists to help prevent and treat infections.
Dr. Chang

Dr. Chang earned his medical degree from Robert Wood Johnson Medical School. He then completed his residency in Pediatrics at Children’s Medical Center of Dallas- UT Southwestern Medical Center and a fellowship in Pediatric Infectious Diseases at Children’s Hospital of Philadelphia. 

“I very much enjoy the team aspect of transplant medicine and immunocompromised infectious disease care and working with other specialists to help prevent and treat infections,” Dr. Chang said. 

Dr. Chang is involved with research and has conducted studies about how to better treat and prevent viral and fungal infections in people who are immunocompromised. 

Outside of work, Dr. Chang enjoys spending time with his wife and two children. He also enjoys hiking and trying new restaurants. 

Education and Training

Medical School
Robert Wood Johnson Medical School (2010)
Residency
UT Southwestern - Children's Medical Center (2013), Pediatrics
Fellowship
Children's Hospital of Philadelphia (2017), Pediatric Infectious Diseases
Board Certification
American Board of Pediatrics/Infectious Disease

  • Research Interests

    • Viral infections including EBV, CMV, and BK virus, and fungal infections

  • Publications

    Publications

    • Mazari PM, Linder-Basso D, Sarangi A, Chang Y, Roth MJ. Single-round selection yields a new retroviral Env utilizing GPR172A as its host receptor. Proc Natl Acad Sci USA. 2009 Apr;106(14)5848-53. PMID: 19633083
    • He F, Nair GR, Soto CS, Chang Y, Hsu L, Ronzone E, DeGrado WF, Binns AN. Molecular basis of ChvE function in sugar binding, sugar utilization, and virulence in Agrobacterium tumefaciens. J Bacteriol. 2009 Sept;191(18):5802-13. PMID: 19307586
    • Mitchell SL, Chang YC, Feemster K, Cárdenas AM. Implementation of a rapid influenza A/B and RSV direct molecular assay improves emergency department oseltamivir use in paediatric patients. J Med Microbiol. 2018 Mar;67(3):358-363. PMID: 29458688
    • Akinboyo IC, Young RR, Spees LP, Heston SM, Smith MJ, Chang YC, et al. Microbiology and Risk Factors for Hospital-Associated Bloodstream Infections Among Pediatric Hematopoietic Stem Cell Transplant Recipients. Open Forum Infect Dis. 2020 Apr; 7(4): ofaa093. PMID: 32284949
    • Fisher BT, Boge CLK, Xiao R, Shuster S, Chin-Quee D, Allen J, Shaheen S, Hayden R, Suganda S, Zaoutis TE, Chang YC, et al. Multicenter Prospective Study of Biomarkers for Diagnosis of Invasive Candidiasis in Children and Adolescents. Clin Infect Dis. 2022 Aug 25;75(2):248-259. Erratum in: Clin Infect Dis. 2023 Mar 4;76(5):972. PMID: 35134165
    • Chang YC, Young RR, Mavis AM, Chambers ET, Kirmani S, Kelly MS, Kalu IC, Smith MJ, Lugo DJ. Epstein-Barr Virus DNAemia and post-transplant lymphoproliferative disorder in pediatric solid organ transplant recipients. PLoS One. 2022 Oct 18;17(10):e0269766. PMID: 36256635
    • Feldman AG, Beaty BL, Ferrolino JA, Maron G, Weidner HK, Ali SA, Bitterfeld L, Boulware MA, Campbell KM, Carr E, Chapman S, Chang YC, et al. Safety and Immunogenicity of Live Viral Vaccines in a Multicenter Cohort of Pediatric Transplant Recipients. JAMA Netw Open. 2023;6(10):e2337602. doi: 10.1001/jamanetworkopen.2023.37602. PMID: 37824141
    • Mah JK, Tam PCK, Chang YC, Saullo JH, Baker AW, Maziarz EK, Messina JA, Sim B, Abusalem L, Hanna S, Pipeling MR, Snyder LD, Reynolds JM, Wolfe CR, Lee MJ, Alexander BD, Heldman MR. Limited utility of Epstein-Barr virus (EBV) surveillance for predicting post-transplant lymphoproliferative disorders in adult EBV seropositive lung transplant recipients. J Clin Virol. 2025;176:105758. PMID: 39700902
    • Feldman AG, Beaty BL, Ferrolino JA, Maron G, Ali SA, Bitterfeld L, Blatt A, Boulware MA, Campbell KM, Carr E, Cetin B, Chapman S, Chang YC, Cunningham R, Dallas RH, Dantuluri KL, Domenick BN, Ebel NH, Elisofon S, Fawaz R, Foca M, Gans HA, Gopalareddy VV, Gupta NA, Harmann K, Hollenbeck J, Huppler AR, Jaramillo C, Kasi N, Kerkar N, Lerret S, Lobritto SJ, Lopez MJ, Mavis A, Mehra S, Mohandas S, Munoz FM, Mysore KR, Ovchinsky N, Perkins K, Postma S, Pratscher L, Rand EB, Rowe RK, Ruderfer D, Schultz D, Sear K, Sell ML, Sharma TS, Stoll J, Turner J, Valencia Deray KG, Villarin D, Weaver C, Wood P, Woodford-Berry O, Yanni G, Danziger-Isakov LA. Postvaccination Immunogenicity Among Pediatric Solid Organ Transplant Recipients. JAMA Pediatr. 2025:e246778 PMID: 39992645

    Books

    • Book Chapter: Chang YC, & Barbas A (2021). The surgical and immunosuppressive basis for infections in the pediatric solid organ transplant recipient. Pediatric Transplant and Oncology Infectious Diseases (pp.1-9.e3). January 2021. Revision in process
    • Book Chapter: Chang, YC & Chambers EC. Opportunistic Infections in Kidney Transplantation. Feigin and Cherry's Textbook of Pediatric Infectious Diseases, 9th Edition. Publication in process, projected December 2024

  • Professional Activities

    • Member, American Academy of Pediatrics (2010 - present)
    • Member, Pediatric Infectious Diseases Society (2014 - present)

  • Awards and Honors

    • Gold Humanism Honor Society - The Gold Foundatin (2010)

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